Activation of RhoA in Podocytes Induces Focal Segmental Glomerulosclerosis
نویسندگان
چکیده
منابع مشابه
Activation of RhoA in podocytes induces focal segmental glomerulosclerosis.
Proper organization of the actin cytoskeleton is essential for the normal structure and function of podocytes. RhoA modulates actin dynamics but its role in podocyte biology is controversial. Here, we generated transgenic mice that express a constitutively active form of RhoA in a podocyte-specific and doxycycline-inducible manner. Induction of activated RhoA with doxycycline resulted in signif...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2011
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2010111146